AIRWAY MANAGEMENT
AGENT
STANDARD DOSE
(MG/KG)
DOSE IF
HEMODYNAMIC
COMPROMISE COMMENTS
Etomidate 0.2–0.3 0.1–0.2 Rapid onset, short duration. Few hemodynamic efects. Preferred for
hypotensive patients with head injury or coronary artery disease.
Ketamine 1.0–2.0 No diference Longer duration. Sympathetic stimulation, bronchodilation, dreams,
salivation. Preferred for patients with asthma.
Propofol 2.0–2.5 mg/kg given
40 mg every 10
seconds
No diference Slow injection preferred over rapid bolus administration. Rapid bolus
may result in cardiorespiratory depression. Titrate dose to response.
Maintenance doses by infusion are preferred: 0.3–3 mg/kg/hr for
prolonged sedation. Avoid in patients with hypovolemia.
Fentanyl and
midazolam
Fentanyl 1.0–4.0
mcg/kg for pain;
midazolam 5.0–10.0
mg for sedation
Reduce by 50% if
hemodynamically
compromised
Can cause respiratory depression during initial administration. Excellent
for prolonged sedation and pain control, but monitor vital signs often.
Succinylcholine 0.6–1.5 No diference Short-acting. Many contraindications and adverse efects. Clinical
duration 4–6 minutes.
Rocuronium 0.6–1.5 No diference Onset time equal to succinylcholine. Clinical duration 30–60 minutes.
Vecuronium 0.08–0.10 No diference Onset time 2–3 minutes. Clinical duration 25–40 minutes.
TABLE 1: IV INDUCTION AND NEUROMUSCULAR BLOCKING DRUGS FOR RSI/DSI
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